Bladder Cancer

Signs & Symptoms  |  Diagnosis  |  Treatment

Signs and Symptoms of Bladder Cancer
The primary symptom of bladder cancer is blood in the urine (hematuria). Hematuria may be visible to the naked eye (gross) or visible only under a microscope (microscopic) and is usually painless. Other symptoms include frequent urination and pain upon urination (dysuria).

Diagnosis of Bladder Cancer
Diagnosis of bladder cancer includes urological tests and imaging tests. A complete medical history is used to identify potential risk factors (e.g., smoking, exposure to dyes). Laboratory tests may include the following:
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BladderChek® (to detect elevated levels of tumor markers in the urine)
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Urinalysis (to detect microscopic hematuria)
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Urine cytology (to detect cancer cells by examining cells flushed from the bladder during urination)
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Urine culture (to rule out urinary tract infection)
Various imaging tests may also be performed. Intravenous pyelogram (IVP) is the standard imaging test for bladder cancer. In this procedure, a contrast agent (radiopaque dye) is administered through a vein (intravenously) and x-rays are taken as the dye moves through the urinary tract. IVP provides information about the structure and function of the kidneys, ureters, and bladder. Other imaging tests include CT scan, MRI scan, bone scan, and ultrasound.
If bladder cancer is suspected, cystoscopy and biopsy are performed. Local anesthesia is administered and a cystoscope (thin, telescope-like tube with a tiny camera attached) is inserted into the bladder through the urethra to allow the physician to detect abnormalities. In biopsy, tissue samples are taken from the lesion(s) and examined for cancer cells. If the sample is positive, the cancer is staged using the tumor, node, metastases (TNM) system.

Treatment of Bladder Cancer
Treatment for bladder cancer depends on the stage of the disease, the type of cancer, and the patient’s age and overall health. Options include surgery, chemotherapy, radiation, and immunotherapy. Treatments are sometimes combined (e.g., surgery or radiation and chemotherapy).
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